Glutathione In The Human Male

 

 

D’Agostini F, Bagnasco M, Giunciuglio D, et al. Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung metastases in mice. Int. J. Oncology 13:217-224, 1998 Medline

Giralt M, Cervello I, Nogues MR, et al. Glutathione, glutathione S-transferase and reactive oxygen species of human scalp sebaceous glands in male pattern baldness. J. Investig. Dermatol. 107: 154-158, 1996 Medline

Jiminez JJ, Huang HS, Yunis AA. Treatment with ImuVert/N-acetylcysteine protects rats from cyclophosphamide/cytarabine-induced alopecia. Cancer Investig. 10:271-276, 1992 Medline

Kermici M, Pruche F, Roguet R, Prunieras M. Evidence for an age-correlated change in glutathione metabolism enzyme activities in human hair follicle. Mech. Aging Dev. 53: 73-84, 1990 Medline

Puerto AM, Nogues MR, Cervello I, et al. Glutathione S-transferase in normal human anagen hair follicles. Rev. Esp. Fisiol. 50:103-108, 1994 Medline

Sawaya ME. Purification of androgen receptors in human sebocytes and hair. J. Investig. Dermaotol. 98 (6 Suppl): 92S-96S, 1992 Medline

Male Infertility

Aitken RJ. A free radical theory of male infertility. Reprod. Fertil. Dev. 6:19-23, 1994 Medline

Alkan I, Simsek F, Haklar G, et al. Reactive oxygen species production by the spermatozoa of patients with idiopathic infertility: relationship to seminal plasma antioxidants. J. Urology 157: 140-143, 1997 Medline

Gopalakrishnan B, Aravinda S, Pawshe CH, et al. Studies on glutathione S-trasferees important for sperm function: evidence for catalytic activity-in-independent functions. Biochem. J. 15: 231-241, 1998 Medline

Griveau JS, Le Lannou D. Reactive oxygen species and human spermatozoa: physiology and pathology. Int. J. Androl. 20: 61-69, 1997 Medline

Irvine DS. Glutathione as a treatment for male infertility. Rev. Reprod. 1:6-12, 1996 Medline

Lenzi A, Gandini L, Picardo M. A rationale for glutathione therapy. Human Reproduction 13:1419-1422, 1998 Medline

Lenzi A, Lombardo F, Gandidi L., et al. Glutathione therapy for male infertility. Arch. Androl. 29:65-68, 1992 Medline

Lenzi A, Picardo M, Gandini  L, et al. Glutathione treatment of dyspermia: effect on the lipoperoxidation process. Human Reproduction 9: 2044-2050, 1994 Medline

Ochsendorf FR, Buhl R, Bastlein A, Beschmann H. Glutathione in spermatozoa and seminal plasma of infertile men. Human Reproduction 13:353-359, 1998 Medline

Oeda T, Henkle R., Ohmori H, Schill WB. Scavenging effect of N-acetyl-L-cysteine against reactive oxygen species in human semen: a possible therapeutic modality for male factor infertility? Andrologia 29: 125-131, 1997 Medline

Sikka SC. Oxidative stress and role of antioxidants in normal and abnormal sperm function. Front. Biosc. 1:e78-86, 1996 Medline

Sikka SC, Rajasekaran M, Hellstrom WJ. Role of oxidative stress and antioxidants in male infertility. J. Androl. 16(6): 464-481, 1995 Medline

Storey BT. Biochemistry of the induction and prevention of lipoperoxidative damage in human spermatozoa. Mol. Human Repro. 3:203-213, 1997 Medline

Zalata A, Hafez T, Comhaire F. Evaluation of the role of reactive oxygen species in male infertility. Human Repro. 10: 1444-1451, 1995 Medline

The Prostate

Bell, DA, Taylor JA, Paulson DF, et al. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolsim gene glutathione gene glutathione S-transferase MI (GSTM1) that increases susceptibility to bladder cancer. J. Natl. Cancer Inst. 85:1159-1164, 1993 Medline

Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276:1957-1963, 1996 Medline

Clark LC, Dalkin B, Krongrad A, et al. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br. J. Urol. 81:730-734, 1998 Medline

Combs GF Jr., Clark LC, Turnbull BW. Reduction of cancer risk with an oral supplement of selenium. Biomed. Envir. Sci. 10: 227-234, 1997 Medline

Combs GF Jr., Clark LC, Turnbull BW. Reduction of cancer mortality and incidence by selenium supplementation. Med. Klin. 92: (Suppl3):42-45, 1997 Medline

Cookson MS, Reuter VE, Linkov I, et al. Glutathione S-transferase PI (GST-pi) class expression by immunohistochemistry in benign and malignant prostate tissue. J. Urol. 157: 673-676, 1997 Medline

De Marzo, AM, Coffey DS, Nelson WG. New concepts in tissue specificity for prostate cancer and benign prostatic hperplasia. Urology 53 (3 Suppl 3a): 29-39, 1999 Medline

Harries LW, Stubbins MJ, Forman D, et al. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis 18: 641-644, 1997 Medline

Jung K, Seidel B, Rudolph B, et al. Antioxidant enzymes in malignant prostate cell lines and in primary cultured prostatic cells. Free Radic. Biol. Med. 23:127-133, 1997 Medline

Liebman B. Clues to prostate cancer. Nutr. Action Lett. 3: 10-12, 1996

Moskaluk CA, Duray PH, Cowan KH, et al. Immunohistochemical expression of pi-class glutathione S-transferase is down-regulated in adenocarcinoma of the prostate. Cancer 79:1595-1599, 1997 Medline

Murakoshi M, Tagawa M, Inada R., et al. Inhibition of steroid-induced prostatic hyperplasia in rats by treatment with anti-androgen (TZP-4238). Endocr. J. 40:479-488, 1993 Medline

Ripple MO, Henry WF, Rago RP, Wilding G. Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. J. Natl. Cancer Instit. 89:40-48, 1997 Medline

Taguchi Y. Current strategies in managing prostate cancer. Can. J. CME. :107-115, 1997

Tew KD, Clapper ML, Greenberg RE, et al. Glutathione S-trasferases in human prostate. Biochem. Biophys, Acta 926: 8-15, 1987 Medline

Winter ML, Liehr JG. Possible mechanism of induction of benign prostatic hyperplasia by estradiol and dihydrotestosterone in dogs. Toxicol. Appl. Pharmacol. 136: 211-219, 1996 Medline

Yoshizawa K, et al. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J. Natl. Cancer Inst. 90:1219-1224, 1998 Medline