Lung Disease

 

 

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De Flora S, Grassi C,  Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur. Respir. J. 19: 1535-1541, 1997 Medline

Demling R, Ikegami K, Lalonde C. Increased lipid peroxidation and decreased antioxidant activity correspond with death after smoke exposure in the rat. J. Burn Care Rehabil. 16(2Pt1): 104-110, 1995 Medline

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Gressier B, Lebegue S, Gosset P, et al. Protective role of glutathione on alpha ! proteinase inhibitor inactivation by the myeloperoxidase system. Hypothetic study for the therapeutic strategy in the management of smoker’s emphysema. Fundam. Clin. Pharmacol. 8: 518-524, 1994 Medline

Hansen NC, Skriver A, Brorsen-Riis L, et al. Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis. Respir. Med. 88: 531-515, 1994 Medline

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MacNee W. Chronic obstructive pulmonary disease from science to the clinic: the role of glutathione in oxidant-antioxidant balance. Monaldi. Arch. Chest Dis. 52:479-485, 1997 Medline

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Meyer A, Buhl R, Magnussen H. The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis. Eur. Respir. J. 7: 431-436, 1994 Medline

Misso NL, Powers KA, Gillon RL, et al. Reduced platelet glutathione peroxidase activity and serum selenium concentration in atopic asthmatic patients. Clin. Exp. Allergy 26: 838-847, 1996 Medline

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Ortolani O, Gratino F, Leone D, et al. Usefulness of the prevention of oxygen radical damage in the critical patient using the parental administration of reduced glutathione in high doses. Boll. Soc. Ital. Biol. Sper. 68: 239-244, 1992 Medline

Pacht ER, Timerman AP, Lykens MG, Merola AJ. Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome. Chest 100: 1397-1403, 1991 Medline

Parr GD, Huitson A. Oral Fabrol (oral N-acetylcysteine) in chronic bronchitis. Br. J. Dis. Chest 81: 341-348, 1987 Medline

Patterson CE, Rhoades RA. Protective role of sulfhydryl reagents in oxidant lung injury. Exp. lung Res. 14 Suppl: 1005-1019, 1988 Medline

Pearson DJ, Suarez-Mendez VJ, Day JP, Miller PF. Selenium status in relation to reduced glutathione peroxidase activity in aspirin-sensitive asthma. Clin. Exp. Allergy 21: 203-208, 1991 Medline

Portal BC, Richard MJ, Faure HS, et al. Altered antioxidant status and increased lipid peroxidation in children with cystic fibrosis. Amer. J. Clin. Nutr. 61: 843-847, 1995 Medline

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Rasmussen JB, Clennow C. Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis. Eur. Respirol. J. 4: 351-355, 1988 Medline

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Rogers DF, Jeffery PK. Inhibition by oral N-acetylcysteine of cigarette smoke-induced “bronchitis” in the rat. Exp. Lung Res. 10: 267-283, 1986 Medline

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Sala R, moriggi E, Corvasce G, Morelli D. Protection by N-acetylcysteine against pulmonary endothelial cell damage induced by oxidant injury. Eur. Respir. J. 6: 440-446, 1993 Medline

Simon LM, Suttorp N. Lung cell oxidant injury: decrease in oxidant mediated cytotoxicity by N-acetylcysteine. Eur. J. Dis. Suppl. 139: 132-135, 1985 Medline

Suter PM, Domenighetti G, Schaller, et al. N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study. Chest 105: 190-194, 1994 Medline

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Witschi H, Espiritu I, Yu M, Willits NH. The effects of phenethyl isothianate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice. Carcinogenesis 19: 1789-1794, 1998 Medline