Raising GSH Levels

Raising GSH Levels

 

 

Almasio P, Bortolini M, Pagliaro L, et al. Role of s-adenosyl methionine in the treatment of intrahepatic cholestasis. Drugs 40: (S3):111-123, 1990 Medline

Anderson ME. glutathione and glutathione delivery systems. Advances in Pharmacology 38:65-78, 1997 Medline

Anderson ME, Levy EJ, Meister A. Preparation and use of glutathione monoesters. Methods Enzymol. 234: 492-499, 1994 Medline

Anderson M, Powrie F, Puri R, Meister A. Glutathione monoethyl ester: Preparation, uptake by tissues, and conversion to glutathione. Archives Biochemistry and Biophysiology 239:538-548, 1985 Medline

Anonymous, record supplied by publisher. Monograph: Alpha-lipoic acid. Altern. Med Rev. 3: 308-311, 1998

Balansky RB, D’Agostini F, Zanacchi P, De Flora S. Protection by N-acetylcysteine of the histopathological and cytogenic damage produced by exposure of rats to cigarette smoke. Cancer Lett. 64: 123-131, 1992 Medline

Barlow-Walden LR, Reiter RJ, Abe M, et al. Melatonin stimulates brain glutathione peroxidase activity. Neurochem. Int. 26: 497-502, 1995 Medline

Basoglu M, Yilirgan I, Akcay F, et al. Glutathione and nitric oxide concentrations in glutamine-infused rabbits with intestinal ischemia/reperfusion. Eur. J. Clin. Chem. Clin. Biochem. 35: 415-419, 1997 Medline

Bast H, Haenen GR. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochem. Biophys. Acta. 963: 558-561, 1988 Medline

Bast H, Haenen GR. Regulation of lipid peroxidation by glutathione and lipoic acid: involvement of liver microsomal vitamin E free radical reductase. Adv. Exp. Med. Biol. 264: 111-116, 1990 Medline

Baur A, Harrer T, Peukert M, et al. Alpha-lipoic acid is an effective inhibitor of human immuno-deficiency virus (HIV-1) replication. Klin. Wochenschr. 69: 722-724, 1991 Medline

Biewenga GP, Haenen GR, Bast. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. 26: 315-331, 1997 Medline

Birnbaum S, Winitz M, Greenstein J. Quantitative nutritional studies with water soluble, chemically defined diets. III – Individual amino acids as sources of “non-essential” nitrogen. Archives Biochemistry and Biophysiology 72:428-436, 1957 Medline

Bishayee A, Chatterjee M. Selective enhancement of glutathione S-transferase activity in liver and extrahepatic tissues of rat following oral administration of vanadate. Acta. Physiol. Pharmacol. Bulg. 19: 83-89, 1993 Medline

Bishayee A, Chatterjee M. Time course effects of vanadium supplement on cytosolic reduced glutathione level and glutathione S-tranferase activity. Biol. Trace Elem. Res. 48: 275-285, 1995 Medline

Bjorkman L, Langworth S, Lind B, et al. Activity of antioxidative enzymes in erythrocytes and concentration of selenium in plasma related to mercury exposure. J. Trace Elem. Electrolytes Health Dis. 7: 157-164, 1993 Medline

Bongers V, De Jong J, Steen I, et al. Antioxidant-related parameters in patients treated for cancer chemoprevention with N-acetylcysteine. Eur. J. Cancer 31A: 921-923, 1995 Medline

Bounous G, Gold P. The biological activity of undenatured whey proteins. The role of glutathione. Clinical Investigative Medicine 14: 296-309, 1991 Medline

Bounous G, Kongshavn P. Influence of dietary whey proteins on the immune system of mice. Journal of Nutrition 112: 1747-55, 1982 Medline

Bounous G, Letourneau L, Kongshavn P. Influence of dietary protein type on the immune system of mice. Journal of Nutrition 113:1415-21, 1983 Medline

Bounous G, Batist G, Gold P. Immuno-enhancing property of dietary whey protein in mice: Role of glutathione. Clinical Investigative Medicine 12:154-61, 1989 Medline

Bounous G, Shenouda N, Kongshavn P, Osmond D. Mechanism of altered B-cell response induced by changes in dietary protein type in mice. Journal of Nutrition 115:1409-17, 1985 Medline

Bray T, Taylor C. Enhancement of tissue glutathione for antioxidant and immune functions in malnutrition. Biochemistry Pharmacology 47:2113-23, 1994 Medline

Busse E, Zimmer G, Schopohl B, Kornhuber B. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittelforschung 42: 829-831, 1992 Medline

Campos R, Garrido A, Guerra A, Valenzuela A. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta. Med. 55: 417-419, 1989 Medline

Cao Y, Feng Z, Hoos A, Klimberg VS. Glutamine enhances gut glutathione production. J. Parenter. Enteral Nutr. 22: 224-227, 1998 Medline

Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276: 1957-1963, 1996 Medline

Clark LC, Dalkin B, Krongrad A, et al. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br. J. Urol. 81: 730-734, 1998 Medline

Clark LC, Hixson LJ, Combs GF Jr, et al. Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiol. Biomarkers Prev. 2: 41-46, 1993 Medline

Combs GF Jr, Clark LC, Turnbull BW. Reduction of cancer risk with an oral supplement of selenium. Biomed. Environ. Sci. 10: 227-234, 1997 Medline

Conaway CC, Jiao D, Kelloff GJ, et al. Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and beta-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice. Cancer Lett. 124: 85-93, 1998 Medline

Constantinescu A, Pick U, Handelman et al. Reduction and transport of lipoic acid by human erythrocytes. Biochem. Pharmacol. 17;50(2):253-61, 1995 Medline

Costagliola C, Menzione M. Effect of vitamin E on the oxidative stress of glutathione in plasma. clin. Physiol. Biochem. 8: 140-143, 1990 Medline

D’Agostini F, Bagnasco M, Giunciuglio D, et al. Inhibition by N-acetylcysteine of doxorubincin-induced clastogenicity and alopecia, and prevention of primary tumors and micrometastasis in mice. Int. J. Oncol. 13: 217-224, 1998 Medline

Davreux CJ, Soric I, Natens AB, et al. N-acetylcysteine attenuates acute lung injury in the rat. Shock 8: 432-438, 1997 Medline

Denno R, Rounds JD, Faris R, et al. Glutamine-enriched total parenteral nutirition enhance plasma glutathione in the resting state. J. Surg. Res. 15;61(1):35-8, 1996 Medline

Dickerson A. Benefits of nutritional supplements. Council for Responsible Nutrition. 1-68, 1998

Droge W. Cysteine and glutathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine. Pharmacology 46: 61-65, 1993 Medline

Dworkin BM. Selenium deficiency in HIV infection and the acquired immuno-deficiency syndrome (AIDS). Chem. Biol. Interact. 91: 181-186, 1994 Medline

Flagg EW, Coates RJ, Eley JW et al. Dietary glutathione intake in humans and the relationship between intake and plasma total glutathione level. Nutr Cancer 21:33-46, 1994 Medline

Floreani M, Skaper SD, Facci L, et al. Melatonin maintains glutathione homeostasis in kainic acid-exposed rat brain tissues. FASEB J 11: 1309-1315, 1997 Medline

Gregus Z, Stein AF, Varga F, Klassen CD. Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicol. Appl. Pharmacol. 114: 88-96, 1992 Medline

Han D, Handelman G, Marcocci L, et al. Lipoic acid increases de nova synthesis of cellular glutathione by improving cysteine utilization. Biofactors 6: 321-338, 1997 Medline

Han D, Tritschler HJ, Packer L. Alpha-lipoic acid increases intracellular glutathione in a human T-lumphocyte Jurkat cell line. Biochem. Biophys. Res. Commun. 207: 258-264, 1995 Medline

Hara M, Abe M, Suzuki T, Reiter RJ. Tissue changes in glutathione metabolism and lipid peroxidation induced by swimming are partially prevented by melatonin. Pharmacol. Toxicol. 78: 308-312, 1996 Medline

Harward TR, Coe D, Souba WW, et al. Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. J. Surg. Res. 56(4):351-5, 1994 Medline

Health Canada. Nutrition recommendations: The report of the Scientific Review Committee. Health Canada, 1990

Hirai R, Kakai S, Kikuishi H, Kawai K. Evaluation of the immunological enhancement activities of Immunocal. Otsuka Pharm Co. Dec. 13,1990

Holdiness MR. Clinical pharmacokinetics of N-acetylcysteine. Clin. Pharmacokinet. 20: 123-134, 1991 Medline

Hong RW, Rounds JD, Helton WS, et al. Glutamine preserves liver glutathione after lethal hepatic injury. Ann. Surg. 215: 114-119, 1992 Medline

Institute of Medicine, Food and Nutrition Board. Public policy news – Translating the science behind the dietary reference intakes. J. American Diet. Assoc. 98: 756, 1998 Medline

Ip C. Comparative effects of antioxidants on enzymes involved in glutathione metabolism. Life Sci. 34: 2501-2506, 1984 Medline

Jacob C, Maret W, Vallee BL. Selenium redox biochemistry of zinc-sulfur coordination sites in proteins and enzymes. Proc. Natl. Acad. Sci. USA. 96: 1910-1914, 1999 Medline

Jain A, Madsen DC, Auld P, et al. L-2-Oxothiazolidine-4-carboxylate, a cysteine precursor, stimulates growth and normalized tissue glutathione concentrations in rats fed a sulfur amino acid-deficient diet. J. Nutr. 125: 851-856, 1995 Medline

Jiang LJ, Maret W, Vallee BL. The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase. Proc. Natl. Acad. Sci. USA. 95: 3483-3488, 1998 Medline

Johnston CS, Meyer CG, Srilakshmi JC. Vitamin C elevates red blood cell glutathione in healthy adults. American J. Clin. Nutri. 58: 103-105, 1993 Medline

Kalayjian RC, Skowron G, Emgushov RT, et al. A phaseI/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects. J. Acq. Immune Def. Syndr. 7: 369-374, 1994 Medline

Kalebic T, Kinter A, Poli G, et al. Suppression of human immunodeficiency virus expression in chronically infected monocyte cells by glutathione, glutathione ester, and N-acetylcysteine. Proc. Natl. Acad. Sci. USA. 88: 986-990, 1991 Medline

Kaplowitz N, Aw T, Ookhtens M. The regulation of hepatic glutathione. Ann Revue Pharmacology and Toxicology 25:715-44, 1985 Medline

Kelly GS. Clinical applications of N-acetylcysteine. Altern. Med. Rev. 3: 114-127, 1998 Medline

Klatz R. Grow young with HGH. [ISBN 0060984341] Harper Perennial. 1997

Klimberg VS, Mc Clellan JL. Claude H. Organ Jr. Honorary Lectureship. Glutamine, cancer, and its therapy. American J. Surg. 172: 418-424, 1996 Medline

Koch S, Leis A, Stokic D, Khawfi F et al. Side effects of IV N-acetylcysteine. American Journal Respirology and Critical Care Medicine 149: A321, 1994

Kotler M, Rodriguez C, Sainz RM, et al. Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J. Pineal Research 24: 83-89, 1998 Medline

Lederman MM, Georger D, Dando S, et al. L-2-Oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain. J. Acq. Immune Def. Syndr. 8: 107-115, 1995 Medline

Levy EJ, Anderson ME, Meister A. Transport of glutathione diethyl ester into human cells. Proc. Natl. Acad. Sci. U.S.A. 90: 9171-9175, 1993 Medline

Levy EJ, Anderson ME, Meister A. Preparation and properties of glutathione diethyl ester and related derivatives. Methods Enzymol. 234: 499-504, 1994 Medline

Lieberman S, Bruning N. The Real Vitamin and Mineral Book. Second Ed. Avery Pub., NY, 1997

Lockitch G. Selenium: clinical significance and analytical concepts. Crit. Rev. Clin. Lab. Sci. 27: 483-541, 1989 Medline

Lomaestro B, Malone M. Glutathione in health and disease: Pharmacotherapeutic Issues. Annals of Pharmacotherapy 29:1263-73, 1995 Medline

Look MP, Rockstroh JK, Rao GS, et al. Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-I (HIV-I)-infection. Eur. J. Clin. Nutr. 51: 266-272, 1997 Medline

Mant T, Tempowski J, Volans G, Talbot J. Adverse reactions to acetylcysteine and effects of overdose. British Medical Journal 289:217-19, 1984 Medline

May JM, Mendiratta S, Hill KE, Burk RF. Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioreoxin reductase. J. Biol. Chem. 272: 22607-22610, 1997 Medline

Meister A. Glutathione. Ann Revue Biochemistry 52:711-60, 1983 Medline

Meister A. New aspects of glutathione bio-chemistry and transport, selective alteration of glutathione metabolism. Nutrition Revue 42:397-410, 1984 Medline

Mendiratta S, Qu ZC, May JM. Erythrocyte ascorbate recycling: antioxidant effects in blood. Free Radic Biol Med. 1998 Mar 15;24(5):789-97 Medline

Miguez MP, Anundi I, Sainz-Pardo LA, Lindros KO. Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2E1. Chem Biol Interact. 1994 Apr;91(1):51-63 Medline

Misso NL, Powers KA, Gillon RL, Stewart GA, Thompson PJ. Reduced platelet glutathione peroxidase activity and serum selenium concentration in atopic asthmatic patients. Clin Exp Allergy. 1996 Jul;26(7):838-47 Medline

Muzes G, Deak G, Lang I, Nekam K, Niederland V, Feher J.[Effect of silimarin (Legalon) therapy on the antioxidant defense mechanism and lipid peroxidation in alcoholic liver disease (double blind protocol)] Orv Hetil. 1990 Apr 22;131(16):863-6. Hungarian. Medline  

Nath KA, Salahudeen AK. Autoxidation of cysteine generates hydrogen peroxide: cytotoxicity and attenuation by pyruvate. Am J Physiol. 1993 Feb;264(2 Pt 2):F306-14 Medline

Nishiuch Y, Sasaki M, Nakayasu M, Oikawa A. Cytotoxicity of cysteine in culture media. In Vitro. 1976 Sep;12(9):635-8 Medline

Olney JW, Ho OL, Rhee V. Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system. Exp Brain Res. 1971;14(1):61-76 Medline

O’Riordain MG, De Beaux A, Fearon KC. Effect of glutamine on immune function in the surgical patient. Nutrition. 1996 Nov-Dec;12(11-12 Suppl):S82-4 Medline

Pablos MI, Agapito MT, Gutierrez R, Recio JM, Reiter RJ, Barlow-Walden L, Acuna-Castroviejo D, Menendez-Pelaez A. Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks. J Pineal Res. 1995 Oct;19(3):111-5 Medline

Pablos MI, Chuang J, Reiter RJ, Ortiz GG, Daniels WM, Sewerynek E, Melchiorri D, Poeggeler B. Time course of the melatonin-induced increase in glutathione peroxidase activity in chick tissues. Biol Signals. 1995 Nov-Dec;4(6):325-30 Medline

Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78 Medline

Packer L, Witt EH, Tritschler HJ. alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med. 1995 Aug;19(2):227-50 Medline

Porta P, Aebi S, Summer K, Lauterburg BH. L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human. J Pharmacol Exp Ther. 1991 Apr;257(1):331-4 Medline

Puri R, Meister A. Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidney. Proceedings of the National Academy of Science USA 80:5258-60, 1983 Medline

Redman C, Scott JA, Baines AT, Basye JL, Clark LC, Calley C, Roe D, Payne CM, Nelson MA. Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Lett. 1998 Mar 13;125(1-2):103-10 Medline

Reiter R, Tang L, Garcia JJ, Munoz-Hoyos A. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci. 1997;60(25):2255-71Medline

Reiter RJ, Tan DX, Cabrera J, D’Arpa D, Sainz RM, Mayo JC, Ramos S. The oxidant/antioxidant network: role of melatonin. Biol Signals Recept. 1999 Jan-Apr;8(1-2):56-63 Medline

Roederer M, Staal FJ, Ela SW, Herzenberg LA, Herzenberg LA. N-acetylcysteine: potential for AIDS therapy. Pharmacology. 1993;46(3):121-9 Medline

Rouse K, Nwokedi E, Woodliff JE, Epstein J, Klimberg VS. Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism. Ann Surg. 1995 Apr;221(4):420-6 Medline

Saez G, Thornally PJ, Hill HAO, et al. The production of free radicals during the oxidation of cysteine and their effects on isolated rat hepatocytes. Biochem Biophys Acta 719:24-31, 1982 Medline

Selhub J, Jacques PF, Bostom HG, D’Agostino RB, Wilson PWF, Belanger AJ, O’Leary DH. Wolf PA, Schaefer EJ, Rosenberg IH. Association between plasma homocysteine concentrations and extracranial carotidartery stenosis. The New England Journal of Medicine 332:286-291, 1995 Medline

Shear NH, Malkiewicz IM, Klein D, Koren G, Randor S, Neuman MG. Acetaminophen-induced toxicity to human epidermoid cell line A431 and hepatoblastoma cell line Hep G2, in vitro, is diminished by silymarin. Skin Pharmacol. 1995;8(6):279-91 Medline

Souba WW. Glutamine and cancer. Ann Surg. 1993 Dec;218(6):715-28 Medline

Stadtman TC. Specific occurrence of selenium in enzymes and amino acid tRNAs. FASEB J. 1987 Nov;1(5):375-9 Medline

Stone J, Hinks LJ, Beasley R, Holgate ST, Clayton BA. Reduced selenium status of patients with asthma. Clin Sci (Lond). 1989 Nov;77(5):495-500 Medline

Vale JA, Buckley BM. Asthma associated with N-acetylcysteine infusion and paracetamol poisoning. Brit Medical Journal 287:1223,1983 Medline

Vale JA, Wheeler DC. Anaphylactoid reactions to acetylcysteine. Lancet 2:998, 1982 Medline

Valenzuela A, Aspillaga M, Vial S, Guerra R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Med. 1989 Oct;55(5):420-2 Medline

Valenzuela A, Garrido A. Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin. Biol Res. 1994;27(2):105-12 Medline

van Zandwijk N. N-acetylcysteine for lung cancer prevention. Chest. 1995 May;107(5):1437-41Medline

Walton NG, Mann TAN, Shwa KM. Anaphylactoid reactions to N-acetylcysteine. Lancet 2:1298, 1979 Medline

Witschi A, Reddy S, Stofer B, Lauterberg B. The systemic availability of oral glutathione. European J of Clin Pharmac 43:667-9, 1992 Medline

Yoshida S, Kaibara A, Yamasaki K, Ishibashi N, Noake T, Kakegawa T. Effect of glutamine supplementation on protein metabolism and glutathione in tumor-bearing rats. JPEN J Parenter Enteral Nutr. 1995 Nov-Dec;19(6):492-7 Medline

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