Cancer
Cancer
Ames BN. Understanding the causes of aging and cancer. Microbiologia 11: 305-308, 1995 Medline
Balansky RB, D’Agostini F, Zanacchi P, et al. Protection of N-acetylcysteine of the histopathological and cytogenetic damage produced by exposure of rats to cigarette smoke. Cancer Lett. 64: 123-131, 1992 Medline
Balansky RM, De Flora S. Chemoprevention by N-acetylcysteine of urethane-induced clastogenicity and lung tumors in mice. Int. J. Cancer 77: 302-305, 1998 Medline
Baruchel S, Viau G. In Vitro selective modulation of cellular glutathion by a humanized native milk protein isolate in normal cells and rat mammary carcinoma model. Anticancer Research 16:1095-1100, 1996 Medline
Baruchel S, Viau G, Olivier R, Bounous G, Wainberg M. Nutriceutical modulation of GSH with a humanized native milk serum protein isolate, Immunocal: application in AIDS and cancer. In: Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases. Institute Pasteur. Pub. Marcel Dekker Inc. 1996
Barta O, Barta VD, Crisman MV, Akers RM. Inhibition of blastogenesis by whey. American J. Vet. Res. 52: 247-253, 1991 Medline
Bell DA, Taylor JA, Paulson DF, et al. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J. Natl. Cancer Inst. 85: 1159-1164, 1993 Medline
Beutler E, Gelbart T. Plasma glutathione in health and in patients with malignant disease. Journal of Laboratory and Clinical Medicine 105: 581-584, 1985 Medline
Bhattathiri VN, Sreelekha TT, Sebastian P, et al. Influence of plasma GSH level on acute radiation mucositis of the oral cavity. Int. J. Radiot. Oncol. Biol. Phys. 29: 383-386, 1994 Medline
Bongers V, De Jong J, Steen I, et al. Antioxidant-related parameters in patients treated for cancer chemoprevention with N-acetylcysteine. Eur. J. Cancer 31: 921-923, 1995 Medline
Boone CW, Kelloff GJ. Biomarker end-points in cancer chemoprevention trials IARC Sci. Publ. 142: 273-280, 1997 Medline
Bounous G, Batist G, Gold P. Whey proteins in cancer prevention. Cancer Letters 57:91-94, 1991 Medline
Bounous G, Papenberg R, Kongshavn P, Gold P, Fleiszer D. Dietary whey protein inhibits the development of dimethyl-hydrazine induced malignancy. Clinical and Investigative Medicine 11:213-217, 1988 Medline
Bourtourault M, Buleon R, Samperez S, et al. Effect of proteins from bovine milk serum on the miltiplication of human cancerous cells. C. S. Seances Soc. Biol. Fil. 185: 319-323, 1991 Medline
Bray TM, Taylor CG. Enhancement of tissue glutathione for antioxidant and immune functions in malnutrition. Biochemical Pharmacology 47:2113-2123, 1994 Medline
Burt TM. Cohorts with familial disposition for colon cancers in chemoprevention trials. Journal of Cellular Biochemistry – Supplement 25: 131-135, 1996 Medline
Clark LC, Combs DF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 277: 1520, 1997 Medline
Clark LC, Dalkin B, Krongrad A, et al. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br. J. Urol. 81: 730-734, 1998 Medline
Clark LC, Hixson LJ, Combs GF Jr, et al. Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiol. Biomarkers Prev. 2: 41-46, 1993 Medline
Combs GF Jr, Clark LC, Turnbull BW. Reduction of cancer mortality and incidence by selenium supplementation. Med Klin. 92 (Suppl3): 42-45, 1997 Medline
Conaway CC, Jiao D, Kelloff GJ, et al. Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and beta-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice. Cancer Lett. 124: 85-93, 1998 Medline
D’Agostini F, Bagnasco M, Giunciuclio D, et al. Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice. Int. J. Oncol. 13: 217-224, 1998 Medline
De Flora S, et al. Antioxidant activity and other mechanisms of thiols involved in chemoprevention of mutation and cancer. The American Journal of Medicine 91: 3c-122S-3c-130s, 1991 Medline
De Flora S, Cesarone CF, Balansky RM, et al. Chemopreventive properties and mechanisms of N-Acetylcysteine. The experimental background. J. Cell Biochem. Suppl. 22: 33-41, 1995 Medline
Delneste Y, Jeannin P, Potier L, et al. N-acetyl-L-cysteine exhibits antitumoral activity by increasing tumor necrosis factor alpha-dependent T-cell cytotoxicity. Blood 90: 1124-1132, 1997 Medline
Dreher D, Junod AF. Role of oxygen free radicals in cancer development. Eur. J. Cancer 32: 30-38, 1996 Medline
Droge W, Gross A, Hack V, Kinscherf R, Schykowski M, Bockstette M, Mihm S, Galter D. Role of cysteine and glutathione in HIV infection and cancer cachexia: Therapeutic intervention with n-acetylcysteine. Advances in Pharmacology 38:581-600 Medline
Guengerich FP, Their R, Persmark M, et al. Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk. Pharmacogenetics 5 Spec. No: S103-107, 1995 Medline
Harries LW, Stubbins MJ, Forman D, et al. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis 18: 641-644, 1997 Medline
Heckbert SR, Weiss NS, Hornung SK, et al. Glutathione S-transferase and epoxide hydrolase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancers. J. Natl. Cancer Inst. 84: 414-422, 1992 Medline
Hietanen E, Bartsch H, Bereziat JC, et al. Diet and oxidative stress in breast, colon and prostate cancer patients: a case-control study. Eur. J. Clin. Nutr. 48: 575-586, 1994 Medline
Izzotti A, Orlando M, Gasparini L, et al. In vitro inhibition by N-acetylcysteine of oxidative DNA modifications detected by 32P postlabeling. Free Radic. Res. 28: 165-178, 1998 Medline
Jimenez JJ, Huang HS, Yunis AA. Treatment with ImuVert/N-acetylcysteine protects rats from cyclophosphamide/cytarabine-induced alopecia. Cancer Invest. 10: 271-276, 1992 Medline
Kennedy RS, Konok JP, Bounous G, Baruchel S, Lee TDG. The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: A phase I-II clinical study. Anticancer Research 15:2643-2650, 1995 Medline
Ketterer B, Harris JM, Talaska G, et al. The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer. Environmental Health Perspectives 98: 87-94, 1992 Medline
Kobrinsky NL, Hartfield D, Horner H, et al. Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest. 14: 202-210, 1996 Medline
Lenton KJ, Therriault H, Fulop T, et al. Glutathione and ascorbate are negatively correlated with oxidative DNA damage in human lymphocytes. Carcinogenesis 20: 607-613, 1999 Medline
McIntosh GH, Regester GO, Leu RK, Royle PJ, Smithers GW. Dairy proteins protect against dimethyl-hydrazine induced intestinal cancers in rats. Journal of Nutrition 125:809-816, 1995 Medline
Mohandas J, Marshall JJ, Duggin GG, et al. Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res. 44: 5086-5091, 1984 Medline
Mulders TMT, Keizer HJ, Breimer DD, Mulder GJ. In Vivo characterization and modulation of the glutathion/glutathione S-transferase system in cancer patients. Drug Metab. Rev. 27: 191-229, 1995 Medline
Nakanishi Y, Matsuki H, Takayama K, et al. Glutathione derivatives enhance Adriamycin cytotoxicity in a human lung adenocarcinoma cell line. Anticancer Res. 17: 2129-2134, 1997 Medline
O’Dwyer PJ, Hamilton TC, Yao K, Tew KD, Ozois RF. Modulation of glutathione and related enzymes in reversal of resistance to anti-cancer drugs. Hematology / Oncology Clinics of North America 9(2):383-396, 1995 Medline
Papenberg R, Bounous G, Fleiszer D, Gold P. Dietary whey proteins inhibit the development of dimethyl-hydrazine induced malignancy. Tumor Biology 11:129-136, 1990 Medline
Plaxe S, Freddo J, Kim S, et al. Phase I trial of cisplatin in combination with glutathione. Gynecologic Oncology 55: 82-86, 1994 Medline
Redman C, Scott JA, Baines AT, et al. Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Lett. 125: 103-110, 1998 Medline
Richie JP Jr. The role of glutathione in aging and cancer. Experimental Gerontology 27:615-626, 1992 Medline
Ripple MO, Henry WF, Rago RP, Wilding G. Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. Journal of the National Cancer Institute 89:40-48, 1997 Medline
Ross RK, Jones PA, Yu MC. Bladder cancer epidemiology and pathogenesis. Seminars in Oncology. 23: 536-545, 1996 Medline
Ross DA, Kish P, Muraszko KM, et al. Effect of dietary vitamin A or N-acetylcysteine on ethylnitrosourea-induced rat gliomas. J. Neurooncol. 40: 29-38, 1998 Medline
Rotstein JB, Slaga TJ. Effect of exogenous glutathione on tumor progression in the murine skin multistage carcinogenesis model. Carcinogenesis 9: 1547-1551, 1988 Medline
Russo A, De Graff W, Friedman N, et al. Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs. Cancer Res. 46: 2845-2848, 1986 Medline
Schroder CP, Godwin AK, O’Dwyer PJ, Tew KD, Hamilton TC, Ozois RF. glutathione and drug resistance. Cancer Investigation 14:158-168, 1996 Medline
Schwartz JL, Shklar G. Glutathione inhibits experimental oral carcinogenesis, p53 expression, and angiogenesis. Nutrition & Cancer 26: 229-236, 1996 Medline
Shklar G, Schwartz J, Trickler D. Cheverie SR. The effectiveness of a mixture of beta-carotene, alpha-tocopherol, glutathione, and ascorbic acid for cancer prevention. Nutrition and Cancer 20: 145-151, 1993 Medline
Singh DK, Lippman SM. Cancer chemoprevention. Part 1: Retinoids and carotenoids and other classic antioxidants. Oncology (Huntingt.) 12: 1643-1653, 1657-1660, 1998 Medline
Singh DK, Lippman SM. Cancer chemoprevention. Part 2: hormones, nonclassic antioxidant natural agents, NSAIDs and other agents. Oncology (Huntingt.) 12: 1787-1800, 1998 Medline
Smyth JF, Bowman A, Perren T, Wilkinson, P Prescott RJ, Quinn KJ, Tedeschi M. GSH reduces the toxicity and improves the quality of life of women diagnosed with ovarian cancer treated with cisplatin: results of a double blind, randomized trial. Annals of Oncology 8:569-573, 1997 Medline
Trickler D, Shklar G, Schwartz J. Inhibition of oral cacinogenesis by glutathione. Nutr. Cancer 20: 139-144, 1993 Medline
Tsuyuki S, Yamauchi A, Nakamura H, et al. Possible availability of N-acetylcysteine as an adjunct to cytokine therapy for hepatocellular carcinoma. Clin. Immunol. Immunopathol. 88: 192-198, 1998 Medline
Van Zandwijk N. N-acetylcysteine for lung cancer prevention. Chest 107: 1437-1441, 1995 Medline
Van Zandwijk N. N-acetylcysteine (NAC) and glutathione (GSH): antioxidant and chemopreventive properties, with speical reference to lung cancer. J. Cell Biochem. Suppl. 22: 24-32, 1995 Medline
Vos O, Roos-Verhey SD. Endogenous versus exogenous thiols in radioprotection. Pharmacological Therapeutics 39:169-177, 1988 Medline
Wang T, Chen X, Schecter RL, Baruchel S, Alaoui_Jamal M, Melnychuk, Batist G. Modulation of GSH by a cysteine pro-drug enhances in vivo tumor response. Journal of Pharmacology and Experimental Therapeutics 276:1169-1173, 1996 Medline
Weisburger JH. Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants and carotinois. American Journal of Clinical Nutrition 53:226s-237s, 1991 Medline
White EL, Ross LJ, Steele VE, et al. Screening of potential cancer preventing chemicals as antioxidants in an in vitro assay. Anticancer Res. 18: 769-773, 1998 Medline
Witschi H, Espiritu I, Yu M, et al. The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice. Carcinogenesis 19: 1789-1794, 1998 Medline
Yim CY, Hibbs JB Jr, McGregor JR, et al. Use of N-acetylcysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J. Immunol. 152: 5796-5805, 1994 Medline