Digestive Disease – Stomach Disease

Digestive Disease – Stomach Disease



Altomare E, Grattagliano I, Didanna D, et al. Gastric and intestinal ethanol toxicity in the rat. Effect on glutathione level and role of alcohol and acetaldehyde metabolisms. Ital. J. Gastroenterol Hepatol. 30:82-90. 1998 Medline

Aruzagaga S, Kavitha K, Nagini S. Erythrocyte lipid peroxidation and antioxidants in gastric cancer patients. Cell. Biochem. Funct. 15:15-18, 1997 Medline

Balint GA. A novel approach to reduce the unwanted gastric side-effects of orally administered non-steroidal anti-inflammatory drugs in rats. Exp. Toxicol. Pathol. 49:61-63, 1997 Medline

Davydenko OM, Kolomoiets MIU, Davydenko IS. Free-radical oxidation, the glutathione system and the status of the gastric mucosa in peptic ulcer in adolescents and young people under dynamic restoration treatment. Lik Sprava 7-8:60-64, 1994 Medline

Eapen CE, Madesh M, Balasubramanian KA, et al. Mucosal mitochondrial function and antioxidant defenses in patients with gastric carcinoma. Scand. J. Gastroenterol. 33:957-981, 1998 Medline

Farinati F, Della Libera G, Cardin R, et al. Gastric antioxidant, nutrites, and mucosal lipoperoxidation in chronic gastritis and Heliobacter pylori infection. J. Clin. Gastroenterol. 22:275-281, 1996 Medline

Giorgi G, Micheli L, Segre G, Pecchi A. Glutathione (GSH) in human stomach mucosa. Riv. Eur. Sci. Med. Farmacol. II:163-167, 1989 Medline

Hahm KB, Lee KJ, Kim YS, et al. Augmented eradication rates of Heliobacter pylori by new combination therapy with lansoprazole, amoxicillin, and rebamipide. Dig. Dis. Sci. 43:235-240, 1998 Medline

Hirokawa K, Kawasaki H. Changes in glutathione in gastric mucosa of gastric ulcer patients. Res. Commun. Mol. Pathol. Pharmacol. 88:163-176, 1995 Medline

Kotah T, Nagata N, Kuroda Y, et al. Glutathione S-transferase Mi (GSTM1) and Ti (GSTTi) genetic polymorphism and susceptibility to gastric and colorectral adenocarcinoma. Carcinogenesis 17:1855-1859, 1996 Medline

Kurokawa T, Joh T, Ikai M, et al. Rebamipide protects against oxygen radical-mediated gastric mucosal injury in rats. Dig. Dis. Sci. 43 (9 Suppl):113S-117S, 1998 Medline

Moghadasian MH, Godin DV. Ethanol-induced gastrointestinal damage. Influence of endogenous antioxidant components and gender. Digestive Disease Sci. 41:791-797, 1996 Medline

Pasechnikov VD, Mosin VI, Vigranskii AO. Lipid peroxidation and the antioxidant enzyme system of the gastric mucosa in peptic ulcer. Ter. Arkh 60 (2):30-3 1988 Medline

Sakuri K, Osaka T, Yamasaki K. Protection by rebamipide against acetic acid-induced colitis in rats: relationship with its antioxidative activity. Dig. Dis. Sci. 43 (9 Suppl):125S-133S, 1998 Medline

Yoshikawa T, Minimiyama Y, Ichkawa H, et al. Role of lipid peroxidation and antioxidants in gastric mucosal injury induced by the hypoxanthine-xanthine oxidase system in rats. Free Radic. Biol. Med. 23:243-250, 1997 Medline

Zala G, Flury R, Wust , et al. Omeprazole/amoxicillin: improved eradication of Heliobacter pylori in smokers because of N-acetylcysteine. Schweiz. Med. Wochenschr. 124:1391-1397. 1994 Medline


Braganza JM, Scott P, Bilton D, et al. Evidence for early oxidative stress in acute pancreatitis. Clues for correction. Int. J. Pancreatol. 17:69-81, 1995 Medline

Gukovsky I, Gukovskaya AS, Blinman TA, et al. Early NF-kappa B activation is associated with hormone-induced pancreatitis. American J. Physiol. 275:(6 pt1):G1402-1414, 1998 Medline

Luthen R, Grendell JH, Haussinger D, Niederau C. Beneficial effects of L-2-oxothiazolidine-4-carboxylate on cerulein pancreatitis in mice. Gastroenterology 112:1681-1691, 1997 Medline

Luthen R, Grendell JH, Niederau C, Haussinger D. Trypsinogen activation and glutathione content are linked to pancreatic injury in models of biliary acute pancreatitis. Int. J. Pancreatol. 24:193-202, 1998 Medline

Luthen R, Niederau C, Grendell JH. Intrapancreatic zymogen activation and levels of ATP and glutathione during caerulein pancreatitis in rats. American J. Physiol. 268:(4 pt1):G592-604, 1995 Medline

Mathew P, Wyllie R, Van Lente F, et al. Antioxidants in hereditary pancreatitis. American J. Gastroenterology 61:1558-1562, 1996 Medline

McCloy R. Chronic pancreatitis at Manchester UK. Focus on antioxidant therapy. Digestion 59 (Suppl 4):36-48, 1998 Medline

Schoenberg MH, Birk D, Berger HG. Oxidative stress in acute and chronic pancreatitis. American J Clin. Nutr. 62(Suppl6):1306S-1314S, 1995 Medline

Schoenberg MH, Buchler M, Younes M, et al. Effect of antioxidant treatment in rats with acute hemorrhagic pancreatitis. Dig. Dis. Sci. 39:1034-1040, 1994 Medline

Walling MA. Xenobiotic metabolism, oxidant stress and chronic pancreatitis: Focus on glutathione. Digestion 59 (Suppl4):13-24, 1998 Medline

Wang XD, Deng XM, Haraldson P, et al. Antioxidant and calcium channel blockers counteract endothelial barrier injury induced by acute pancreatitis in rats. Scand. J. Gastroenterol. 30:1129-1136, 1995 Medline

Inflammatory Bowel Disease

Ahnfelt-Ranne I, Nielsen OH, Christensen A, et al. Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid. Gastroenterology 98:1162-1169, 1990 Medline

Bhaskar L, Ramakrishna BS, Balasubramanian KA. Colonic mucosal antioxidant enzymes and lipid peroxide levels in normal subjects and patients with ulcerative colitis. J. Gastroent. Hepatol. 10:140-143, 1995 Medline

Buffington GD, Doe WF. Depleted mucosal antioxidant defenses in inflammatory bowel disease. Free Radic. Biol. Med. 19:911-918, 1995 Medline

Bulger EM, Helton WS. Nutrient antioxidants in gastrointestinal diseases. Gastrenterol. Clin. North America 27:403-419, 1998 Medline

Cruz T, Galvez J, Ocete MA, et al. Oral administration of rutoside can ameliorate inflammatory bowel disease in rats. Life Sci. 62:687-695, 1998 Medline

Geerling BJ, Badart-Smook A, Stockbrugger RW, Brummer RJ. Comprehensive nutritional status in patients with long-standing Crohn’s disease currently in remission. American J. Clin. Nutr. 67:919-926, 1998 Medline

Grisham MB. Oxidants and free radicals in inflammatory bowel disease. Lancet 344(8926):859-861, 1994 Medline

Gross V, Arndt H, Andus, et al. Free radicals in inflammatory bowel diseases pathophysiology and therapeutic implications. Hepatogastroenterology 41:320-327, 1994 Medline

Hagen TM, Wierzbika GT, Bowman BB, et al. Fate of dietary glutathione: disposition in the gastrointestinal tract. American J. Physiol. 259:G530-G535, 1990 Medline

Harris ML, Schiller HJ, Reilly PM, et al. Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence, or epiphenomenon? Pharmac. Ther. 53:375-408, 1992 Medline

Hoffenber EJ, Deutsch J, Smith S, Sokol RJ. Circulating antioxidant concentrations in children with inflammatory bowel disease. American J. Clin. Nutr. 65:1482-1488, 1997 Medline

Holmes EW, Yong SL, Eizenhamer D, Keshavarian A. Glutathione content of colonic mucosa: evidence for oxidative damage in active ulcerative colitis. Dig. Dis. Sci. 43:1088-1095, 1998 Medline

Iantomasi T, Marraccini P, Favilli F, et al. Glutathione metabolism in Crohn’s disease. Biochem. Med. Metab. Biol. 53:87-91, 1994 Medline

Lih-Brody L, Powell SR, Collier KP, et al. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Digestive Diseases and Sciences 41:2078-2086, 1996 Medline

Martensson J, Jain A, Meister A. Glutathione is required for intestinal function. Proc. Natl. Acad. Sci. USA 87:1715-1719, 1990 Medline

Sido B, Hack V, Hochlehnert A, et al. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut 42:485-492, 1998 Medline

Sokol RJ, Hoffenberg EJ. Antioxidants in pediatric gastrointestinal disease. Pediatr. Clin. North America 43:471-488, 1996 Medline

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