Lung Disease

Lung Disease



Balansky RM, De Flora S. Chemoprevention by N-acetylcysteine of urethane-induced clastogenicity and lung tumors in mice. Int. J. Cancer 77: 302-305, 1998 Medline

Balansky RB, D’Agostinin F, Zannacchi P, De Flora S. Protection of N-acetylcysteine of the histopathological and cytogenetical damage produced by exposure of rats to cigarette smoke. Cancer Lett. 64:123-131, 1992 Medline

Baranova H, Perriot J, Albuisson E, et al. Peculiarities of the GSTM1 o/o genotype in French heavy smokers with various types of chronic bronchitis. Human Genetics 99: 822-826, 1997 Medline

Behr J, Degenkolb B, Maier K, et al. Increased oxidation of extracellular glutathione by bronchoalveolar inflammatory cells in diffuse fibrosing alveolitis. Eur. Respir. J. 8: 1286-1292, 1995 Medline

Behr J, Maier K, Degenkolb B, et al. Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression. American J. Respir. Crit. Care Med. 156: 1897-1901, 1997 Medline

Bernard GR. Potential of N-acetylcysteine as treatment for the adult respiratory distress syndrome. Eur. Respir. J. Suppl. 11:496S-498S, 1990 Medline

Bernard GR. N-acetylcysteine in experimental and clinical acute lung injury. American J. Med. 91: (3c):54S-59S, 1991 Medline

Bernard GR, Wheeler AP, Arons MM, et al. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The antioxidant in ARDS Study Group. Chest 112: 164-172, 1997 Medline

Bibi H, Schlesinger M, Tabachnik E, et al. Erythrocyte glutathione peroxidase activity in asthmatic children. Ann. Allergy 61: 339-340, 1988 Medline

Borok Z, Buhl R, Grimes GJ, et al. Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. Lancet 338: 215-216, 1991 Medline

Brigham KL. Oxidant stress and adult respiratory distress syndrome. Eur. Respir. J. Suppl. 11: 4825-4845, 1990 Medline

Brown RK, Kelly FJ. Evidence for increased oxidative damage in patients with cystic fibrosis. Pediatr. Res. 36: 487-493, 1994 Medline

Buhl R, Meyer A, Vogelmeier C. Oxidant-protease interaction in the lung. Prospects for antioxidant therapy. Chest 110 (6Suppl): 267S-2727S, 1996 Medline

Buhl R, Vogelmeier C. Therapy for lung diseases with anti-oxidants. Pneumologie 48: 50-56, 1994 Medline

Buhl R, Vogelmeier C, Critinden, et al. Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol. Proc. Natl. Acad. Sci. USA 87: 4063-4067, 1990 Medline

Bunnel E, Pacht ER. Oxidized glutathione is increased in the alveolar fluid of patients with the adult respiratory distress syndrome. American Rev. Respir. Dis. 148: 1174-1178, 1993 Medline

Cantin A, Crystal RG. Oxidants, antioxidants and the pathogenesis of emphysema. Eur. J. Dis. Suppl. 139:7-17, 1985 Medline

Cantin A, Hubbard RC, Crystal RG. Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis. American Rev. Respir. Dis. 139: 370-372, 1989 Medline

Cantin A, Larivee P, Begin RO. Extracellular glutathione suppresses human lung fibroblast proliferation. American J. Respir. Cell. Mol. Biol. 3:79-85, 1990 Medline

Cato A, Goldstein I, Millman. A double-blind parallel study of acetylcysteine-isoproterenol and saline-isoproterenol in patients with chronic obstructive lung disease. J. Int. Med. Res. 5:175-183, 1977 Medline

Conaway CC, Jiao D, Kelloff GJ, et al. Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and beta-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice. Cancer Lett. 124:85-93, 1998 Medline

Cotgreave IA, Moldeus P. Lung protection by thiol-containing antioxidants. Bull. Eur. Physiopathol. Respir. 23: 272-277, 1987 Medline

D’Agostini F, Bagnasco M. Giunciuglio D, et al. Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopedia, and prevention of primary tumors and lung metastasis in mice. Int. J. Oncol. 13: 217-224, 1998 Medline

Davreux CJ, Soric I, Nathens AB, et al. N- acetyl cysteine attenuates acute lung injury in the rat. Shock 8: 432-438, 1997 Medline

De Flora S, Grassi C,  Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur. Respir. J. 19: 1535-1541, 1997 Medline

Demling R, Ikegami K, Lalonde C. Increased lipid peroxidation and decreased antioxidant activity correspond with death after smoke exposure in the rat. J. Burn Care Rehabil. 16(2Pt1): 104-110, 1995 Medline

Demling R, Lalonde C, Picard L. Blanchard J. Changes in lung and systemic oxidant and antioxidant activity after smoke inhalation. Shock 1 :101-107, 1994 Medline

Eiserich JP, Van Der Vliet, et al. Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction. American J. Clin. Nutr. 62(6Suppl): 1490S-1500S, 1995 Medline

Goldstein RH, Fine A. Potential therapeutic initiatives for fibrogenic lung diseases. Chest 108: 848-855, 1995 Medline

Greene LS. Asthma and oxidant stress: nutritional, environmental and genetic risk factors. J. American Coll. Nutr. 14: 317-324, 1995 Medline

Gressier B, Lebegue S, Gosset P, et al. Protective role of glutathione on alpha ! proteinase inhibitor inactivation by the myeloperoxidase system. Hypothetic study for the therapeutic strategy in the management of smoker’s emphysema. Fundam. Clin. Pharmacol. 8: 518-524, 1994 Medline

Hansen NC, Skriver A, Brorsen-Riis L, et al. Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis. Respir. Med. 88: 531-515, 1994 Medline

Hasselmark L, Malmgren R, Unge G, Zetterstrom O. Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma. Allergy 45: 523-527, 1990 Medline

Hull J, Vervaart P, Grimwood K, Phelan P. Pulmonary oxidative stress response in young children with cystic fibrosis. Thorax 52: 557-560, 1997 Medline

Hunninghake GW, Kalica AR. Approaches to the treatment of pulmonary fibrosis. American J. Respir. Crit. Care Med. 151(3Pt1): 915-918, 1995 Medline

Ikegami K, Lalonde C, Young YK, et al. Comparison of plasma reduced glutathione and oxidized glutathione with lung and liver tissue oxidant and antioxidant activity during acute inflammation. Shock 1: 307-312, 1994 Medline

Kadrabova J., Mad’aric A, Kovacikova Z, et al. Selenium status is decreased in patients with intrinsic asthma. Biol. Tr. Elem. Res. 52: 241-248, 1996 Medline

Kelly FJ, Cotgrove M, Mudway IS. Respiratory lining tract fluid antioxidants: the first line of defense against serious gaseous pollutants. Cent. Eur. J. Public Health 4 Suppl:11-14, 1996 Medline

Lands LC, Grey VL, Grenier. Total plasma antioxidant capacity in cystic fibrosis. Pediatr. Pulmonol. 29:81-87, 2000 Medline

Laurent T, Markert M, Feihl F, et al. Oxidant-antioxidant balance in granulocytes during ARDS. Effect of N-acetylcysteine. Chest 109: 163-166, 1996 Medline

Lothian B, Grey V, Kimoff RJ, Lands LC. Treatment of obstructive airway disease with a cysteine donor protein supplement: A case report. Chest 117: 914-916, 2000 Medline

MacNee W. Chronic obstructive pulmonary disease from science to the clinic: the role of glutathione in oxidant-antioxidant balance. Monaldi. Arch. Chest Dis. 52:479-485, 1997 Medline

MacNee W, Bridgeman MM, Marsden M, et al. The effects of N-acetylcysteine and glutathione on smoke-induced changes in lung phagocytes and epithelial cells. American J. Med. 91(3C): 60S-66S, 1991 Medline

Meyer A, Buhl R, Kampf S, Magnussen H. Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fibrosis and normals. American J. Respir. Crit. Care Med. 152: 1055-1060, 1995 Medline

Meyer A, Buhl R, Magnussen H. The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis. Eur. Respir. J. 7: 431-436, 1994 Medline

Misso NL, Powers KA, Gillon RL, et al. Reduced platelet glutathione peroxidase activity and serum selenium concentration in atopic asthmatic patients. Clin. Exp. Allergy 26: 838-847, 1996 Medline

Morris PE, Bernard GR. Significance of glutathione in lung disease and implications for therapy. American J. of Med. Sci. 307: 119-127, 1994 Medline

Novak Z, Nemeth I, Gyurkovits K, et al. Examination of the role of oxygen free radicals in bronchial asthma in childhood. Clin. Chim. Acta. 201: 247-251, 1991 Medline

Olivieri D, Marisco SA, Del Donno M. Improvement of mucociliary transport in smokers by mucolytics. Eur. J. Respir. Dir. Suppl. 139: 142-145, 1985 Medline

Ortolani O, Gratino F, Leone D, et al. Usefulness of the prevention of oxygen radical damage in the critical patient using the parental administration of reduced glutathione in high doses. Boll. Soc. Ital. Biol. Sper. 68: 239-244, 1992 Medline

Pacht ER, Timerman AP, Lykens MG, Merola AJ. Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome. Chest 100: 1397-1403, 1991 Medline

Parr GD, Huitson A. Oral Fabrol (oral N-acetylcysteine) in chronic bronchitis. Br. J. Dis. Chest 81: 341-348, 1987 Medline

Patterson CE, Rhoades RA. Protective role of sulfhydryl reagents in oxidant lung injury. Exp. lung Res. 14 Suppl: 1005-1019, 1988 Medline

Pearson DJ, Suarez-Mendez VJ, Day JP, Miller PF. Selenium status in relation to reduced glutathione peroxidase activity in aspirin-sensitive asthma. Clin. Exp. Allergy 21: 203-208, 1991 Medline

Portal BC, Richard MJ, Faure HS, et al. Altered antioxidant status and increased lipid peroxidation in children with cystic fibrosis. Amer. J. Clin. Nutr. 61: 843-847, 1995 Medline

Powell CV, Nash AA, Powers HJ, Primhak RA. Antioxidant status in asthma. Pediatr. Pulmonol. 18: 34-38, 1994 Medline

Rahman I, MacNee W. Role of oxidants/antioxidants in smoking-induced lung diseases. Free Radic. Biol. Med. 21: 669-681, 1996 Medline

Rasmussen JB, Clennow C. Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis. Eur. Respirol. J. 4: 351-355, 1988 Medline

Ruse GC, Larsson P, et al. The intrabronchial microbial flora in chronic bronchitis patients: : a target for N-acetylcysteine therapy? Eur. Respir. J. 7:94-101, 1994 Medline

Rogers DF, Jeffery PK. Inhibition by oral N-acetylcysteine of cigarette smoke-induced “bronchitis” in the rat. Exp. Lung Res. 10: 267-283, 1986 Medline

Roum JH, Buhl R, McElvaney, et al. Systemic deficiency of glutathione in cystic fibrosis. J. Appl. Physiol. 75: 2419-2424, 1993 Medline

Sala R, moriggi E, Corvasce G, Morelli D. Protection by N-acetylcysteine against pulmonary endothelial cell damage induced by oxidant injury. Eur. Respir. J. 6: 440-446, 1993 Medline

Simon LM, Suttorp N. Lung cell oxidant injury: decrease in oxidant mediated cytotoxicity by N-acetylcysteine. Eur. J. Dis. Suppl. 139: 132-135, 1985 Medline

Suter PM, Domenighetti G, Schaller, et al. N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study. Chest 105: 190-194, 1994 Medline

Tanswell AK, Freeman BA. Antioxidant therapy in critical care medicine. New Horiz. 3:330-341, 1995 Medline

Tattersall AB, Bridgman KM, Huitson A. Irish general practice study of acetylcysteine (Fabrol) in chronic bronchitis. J. Int. Med. Res. 12:96-101, 1984 Medline

Teramoto S, Fukuchi Y, Uejima Y, et al. Superoxide anion formation and glutathione metabolism of blood in patients with idiopathic pulmonary fibrosis. Biochem. Mol. Med. 55: 66-70, 1995 Medline

Van Zandwijk N. N-acetylcysteine (NAC) and glutathione: antioxidant and chemopreventative properties, with special reference to lung cancer. J. Cell. Biochem. Suppl. 22:24-32, 1995 Medline

Van Zandwijk N. N-acetylcysteine for lung cancer protection. Chest 107: 1437-1441, 1995 Medline

Vina j, Servera E, Aseni M, et al. Exercise causes blood glutathione oxidation in chronic obstructive pulmonary disease: prevention by O2 therapy. J. Appl. Physiol. 81: 2198-2202, 1996 Medline

Volkl KP, Schneider B. Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2, 512 patients. Fortschr. Med. 110: 346-350, 1992 Medline

Wagner PD, Mathieu-Costello O, Bebout BE, et al. Protection against pulmonary O2 toxicity by N-acetylcysteine. Eur. Respir. J. 2:116-126, 1989 Medline

White CW, Repine JE. Pulmonary antioxidant defense mechanisms. Exp. Lung Res. 8:81-96, 1985 Medline

Winklhofer-Roob BM. Oxygen free radicals and antioxidants in cystic fibrosis: the concept of an oxidant-antioxidant imbalance. Acta. Paediatr. Suppl. 83: 49-57, 1994 Medline

Witschi H, Espiritu I, Yu M, Willits NH. The effects of phenethyl isothianate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice. Carcinogenesis 19: 1789-1794, 1998 Medline

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